Products
Integrin alpha-5 antibody
- Product Name
- Integrin alpha-5 antibody
- Catalogue No.
- FNab04347
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- integrin, alpha 5
- Alternative Names
- CD49e antibody, FNRA antibody, Integrin alpha 5 antibody, Integrin alpha F antibody, ITGA5 antibody, VLA 5 antibody, VLA5A antibody
- UniProt ID
- P08648
- Observed MW
- 120 kDa
Application
- Tested Applications
- ELISA, WB
- Recommended dilution
- WB: 1:500-1:2000
Validated Images
3T3-L1 cells were subjected to SDS PAGE followed by western blot withFNab04347(ITGA5 antibody) at dilution of 1:1000
- Background
- Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. ITGA5:ITGB1 binds to PLA2G2A via a site(site 2) which is distinct from the classical ligand-binding site(site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1(PubMed:18635536, PubMed:25398877). ITGA5:ITGB1 acts as a receptor for fibrillin-1(FBN1) and mediates R-G-D-dependent cell adhesion to FBN1(PubMed:12807887, PubMed:17158881).
